Onconova Implementation Guide - Local Development build (v0.2.0) built by the FHIR (HL7® FHIR® Standard) Build Tools. See the Directory of published versions

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Resource Profile: Medication Administration Profile

A profile representing a medication administered to a cancer patient during a systemic therapy (e.g., chemotherapy, immunotherapy), including details about the medication and dosage.

This profile extends the base mCODE CancerRelatedMedicationAdministration profile to introduce additional information about the systemic therapy (e.g. number of cycles, therapeutic role, etc.) and to introduce references to other medication administration given simultaneously to represent combination therapies.

Since Onocnova treats systemic therapies involving multiple antineoplastic agents administered together or in sequence as part of a single treatment plan, this profile allows for capturing such relationships between medication administrations using the MedicationAdministration.extension[combinedWith] extension slices.

Conformance:

MedicationAdministration resources representing a systemic therapy in the scope of Onconova SHALL conform to this profile. Any resource intended to conform to this profile SHOULD populate meta.profile accordingly.

Usages:

• Refer to this Profile: Adverse Event Profile and Medication Administration Combined With
• CapabilityStatements using this Profile: Onconova FHIR REST Server Capability Statement

You can also check for usages in the FHIR IG Statistics

Formal Views of Profile Content

Description of Profiles, Differentials, Snapshots and how the different presentations work.

• Key Elements Table
• Differential Table
• Snapshot Table
• Statistics/References
• All

Name	Flags	Card.	Type	Description & Constraints    Filter: Bindings Constraints Obligations
MedicationAdministration	C	0..*	CancerRelatedMedicationAdministration	Administration of medication to a patient Constraints: mcode-reason-required, termination-reason-code-invariant, termination-reason-invariant, o-med-req-1, o-med-req-2, o-med-req-3, o-med-req-4
implicitRules	?!Σ	0..1	uri	A set of rules under which this content was created
Slices for extension	S	1..*	Extension	Extension Slice: Unordered, Open by value:url
extension:treatmentIntent	SO	1..1	(Complex)	Procedure Intent Extension URL: http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-procedure-intent Obligations Actor SHALL:populate Creator (Onconova) SHOULD:persist Consumer (Onconova) SHOULD:populate-if-known Creator (Onconova) SHOULD:persist Consumer (Onconova)
extension		0..0		Extension Slice: Unordered, Open by value:url
url		1..1	uri	"http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-procedure-intent"
value[x]		1..1	CodeableConcept	Value of extension Binding: Treatment Intents Value Set (required)
extension:normalizationBasis		0..1	CodeableConcept	Not used in this profile URL: http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-normalization-basis Binding: Normalization Basis Value Set (required)
extension:combinedWith	SO	0..*	Reference(Medication Administration Profile)	Other medication administered in combination URL: http://onconova.github.io/fhir/StructureDefinition/onconova-ext-medication-administration-combined-with Obligations Actor SHALL:populate-if-known Creator (Onconova) SHOULD:persist Consumer (Onconova)
extension:cycles	SO	0..1	integer	Total number of cycles for this medication URL: http://onconova.github.io/fhir/StructureDefinition/onconova-ext-medication-administration-cycles Obligations Actor SHALL:populate Creator (Onconova) SHOULD:persist Consumer (Onconova)
extension:therapyLine	SO	0..1	Reference(Therapy Line Profile)	Reference to the therapy line associated with this treatment URL: http://onconova.github.io/fhir/StructureDefinition/onconova-ext-therapy-line-reference Obligations Actor MAY:ignore Creator (Onconova) MAY:persist Consumer (Onconova)
extension:adjunctiveRole	SO	0..1	CodeableConcept	Role of this medication in the overall treatment plan URL: http://onconova.github.io/fhir/StructureDefinition/onconova-ext-medication-administration-adjunctive-role Binding: Adjunctive Therapy Roles Value Set (required) Obligations Actor SHALL:populate-if-known Creator (Onconova) SHOULD:persist Consumer (Onconova)
extension:isPrimaryTherapy	SO	0..1	boolean	Indicates if this medication is the primary therapy within a therapy line URL: http://onconova.github.io/fhir/StructureDefinition/onconova-ext-medication-administration-is-primary-therapy Obligations Actor MAY:ignore Creator (Onconova) MAY:persist Consumer (Onconova)
modifierExtension	?!	0..*	Extension	Extensions that cannot be ignored
partOf	Σ	0..*	Reference(MedicationAdministration | Procedure)	Not used in this profile
status	?!SΣ	1..1	code	Not used in this profile Binding: MedicationAdministration Status Codes (required): A set of codes indicating the current status of a MedicationAdministration.
statusReason	SO	1..1	CodeableConcept	Reason administration not performed Binding: Treatment Termination Reasons Value Set (required) Obligations Actor SHOULD:populate-if-known Creator (Onconova) SHOULD:persist Consumer (Onconova)
medication[x]	SOΣ	1..1	CodeableConcept	What was administered Binding: Antineoplastic Agents Value Set (required) Obligations Actor SHALL:populate Creator (Onconova) SHOULD:persist Consumer (Onconova)
subject	SOΣ	1..1	Reference(Cancer Patient Profile)	Who received medication Obligations Actor SHALL:populate Creator (Onconova) SHOULD:persist Consumer (Onconova)
context		0..1	Reference(Encounter | EpisodeOfCare)	Not used in this profile
supportingInformation		0..*	Reference(Resource)	Not used in this profile
effective[x]	SOΣ	1..1	Period	Start and end time of administration Obligations Actor SHALL:populate Creator (Onconova) SHOULD:persist Consumer (Onconova)
performer	Σ	0..*	BackboneElement	Not used in this profile
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
actor	Σ	1..1	Reference(Practitioner | PractitionerRole | Patient | RelatedPerson | Device)	Who performed the medication administration
reasonCode	S	0..*	CodeableConcept	Not used in this profile Binding: Cancer Disorder Value Set (extensible)
reasonReference	SO	1..*	Reference(Primary Cancer Condition Profile | Secondary Cancer Condition Profile)	The condition(s) that motivated the medication administration Obligations Actor SHALL:populate Creator (Onconova) SHOULD:persist Consumer (Onconova)
request		0..1	Reference(MedicationRequest)	Not used in this profile
dosage	SC	0..1	BackboneElement	Details of how medication was taken Constraints: mad-1
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
Documentation for this format

Terminology Bindings

Path	Status	Usage	ValueSet	Version	Source
MedicationAdministration.​extension:treatmentIntent.​value[x]	Base	required	Treatment Intents Value Set	📦0.2.0	This IG
MedicationAdministration.​status	Base	required	Medication administration status codes	📍4.0.1	FHIR Std.
MedicationAdministration.​statusReason	Base	required	Treatment Termination Reasons Value Set	📦0.2.0	This IG
MedicationAdministration.​medication[x]	Base	required	Antineoplastic Agents Value Set	📦0.2.0	This IG
MedicationAdministration.​reasonCode	Base	extensible	Cancer Disorder Value Set	📦4.0.0	minimal Common Oncology Data Elements v4.0

Constraints

Id	Grade	Path(s)	Description	Expression
dom-2	error	MedicationAdministration	If the resource is contained in another resource, it SHALL NOT contain nested Resources	contained.contained.empty()
dom-3	error	MedicationAdministration	If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource	contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().as(canonical) | %resource.descendants().as(uri) | %resource.descendants().as(url))) or descendants().where(reference = '#').exists() or descendants().where(as(canonical) = '#').exists() or descendants().where(as(canonical) = '#').exists()).not()).trace('unmatched', id).empty()
dom-4	error	MedicationAdministration	If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated	contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()
dom-5	error	MedicationAdministration	If a resource is contained in another resource, it SHALL NOT have a security label	contained.meta.security.empty()
dom-6	best practice	MedicationAdministration	A resource should have narrative for robust management	text.`div`.exists()
ele-1	error	**ALL** elements	All FHIR elements must have a @value or children	hasValue() or (children().count() > id.count())
ext-1	error	**ALL** extensions	Must have either extensions or value[x], not both	extension.exists() != value.exists()
mad-1	error	MedicationAdministration.dosage	SHALL have at least one of dosage.dose or dosage.rate[x]	dose.exists() or rate.exists()
mcode-reason-required	warning	MedicationAdministration	One of reasonCode or reasonReference SHALL be present	reasonCode.exists() or reasonReference.exists()
o-med-req-1	error	MedicationAdministration	The subject element is required and must be provided.	subject.exists()
o-med-req-2	error	MedicationAdministration	The effectivePeriod element is required and must be provided.	effectivePeriod.exists()
o-med-req-3	error	MedicationAdministration	The treatmentIntent extension is required and must be provided.	extension('http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-procedure-intent').exists()
o-med-req-4	error	MedicationAdministration	The medicationCodeableConcept element is required and must be provided.	medicationCodeableConcept.exists() and medicationCodeableConcept.coding.exists()
termination-reason-code-invariant	error	MedicationAdministration	When status is stopped, only certain statusReason values are allowed	status = 'stopped' and statusReason.exists() and statusReason.coding.exists() implies statusReason.coding.exists(system = 'http://snomed.info/sct' and (code = '182992009' or code = '266721009' or code = '407563006' or code = '160932005' or code = '105480006' or code = '184081006' or code = '309846006' or code = '399307001' or code = '419620001' or code = '7058009' or code = '443729008' or code = '77386006'))
termination-reason-invariant	error	MedicationAdministration	Certain statusReason values are allowed only when status is stopped	statusReason.exists() and statusReason.coding.exists( system = 'http://snomed.info/sct' and (code = '182992009' or code = '266721009' or code = '407563006' or code = '160932005' or code = '105480006' or code = '184081006' or code = '309846006' or code = '399307001' or code = '419620001' or code = '7058009' or code = '443729008' or code = '77386006')) implies status = 'stopped'

This structure is derived from CancerRelatedMedicationAdministration

Name	Flags	Card.	Type	Description & Constraints    Filter: Bindings Constraints Obligations
MedicationAdministration	C	0..*	CancerRelatedMedicationAdministration	Administration of medication to a patient Constraints: o-med-req-1, o-med-req-2, o-med-req-3, o-med-req-4
extension		1..*	Extension	Extension
Slices for extension				Content/Rules for all slices
extension:treatmentIntent	O	1..1	ProcedureIntent	Procedure Intent Extension Obligations Actor SHALL:populate Creator (Onconova) SHOULD:persist Consumer (Onconova) SHOULD:populate-if-known Creator (Onconova) SHOULD:persist Consumer (Onconova)
value[x]		1..1	CodeableConcept	Value of extension Binding: Treatment Intents Value Set (required)
extension:normalizationBasis		0..1	NormalizationBasis	Not used in this profile
extension:combinedWith	O	0..*	Reference(Medication Administration Profile)	Other medication administered in combination URL: http://onconova.github.io/fhir/StructureDefinition/onconova-ext-medication-administration-combined-with Obligations Actor SHALL:populate-if-known Creator (Onconova) SHOULD:persist Consumer (Onconova)
extension:cycles	O	0..1	integer	Total number of cycles for this medication URL: http://onconova.github.io/fhir/StructureDefinition/onconova-ext-medication-administration-cycles Obligations Actor SHALL:populate Creator (Onconova) SHOULD:persist Consumer (Onconova)
extension:therapyLine	O	0..1	Reference(Therapy Line Profile)	Reference to the therapy line associated with this treatment URL: http://onconova.github.io/fhir/StructureDefinition/onconova-ext-therapy-line-reference Obligations Actor MAY:ignore Creator (Onconova) MAY:persist Consumer (Onconova)
extension:adjunctiveRole	O	0..1	CodeableConcept	Role of this medication in the overall treatment plan URL: http://onconova.github.io/fhir/StructureDefinition/onconova-ext-medication-administration-adjunctive-role Binding: Adjunctive Therapy Roles Value Set (required) Obligations Actor SHALL:populate-if-known Creator (Onconova) SHOULD:persist Consumer (Onconova)
extension:isPrimaryTherapy	O	0..1	boolean	Indicates if this medication is the primary therapy within a therapy line URL: http://onconova.github.io/fhir/StructureDefinition/onconova-ext-medication-administration-is-primary-therapy Obligations Actor MAY:ignore Creator (Onconova) MAY:persist Consumer (Onconova)
partOf		0..*	Reference(MedicationAdministration | Procedure)	Not used in this profile
status		1..1	code	Not used in this profile
statusReason	O	1..1	CodeableConcept	Reason administration not performed Binding: Treatment Termination Reasons Value Set (required) Obligations Actor SHOULD:populate-if-known Creator (Onconova) SHOULD:persist Consumer (Onconova)
medication[x]	O	1..1	CodeableConcept	What was administered Binding: Antineoplastic Agents Value Set (required) Obligations Actor SHALL:populate Creator (Onconova) SHOULD:persist Consumer (Onconova)
subject	O	1..1	Reference(Cancer Patient Profile)	Who received medication Obligations Actor SHALL:populate Creator (Onconova) SHOULD:persist Consumer (Onconova)
context		0..1	Reference(Encounter | EpisodeOfCare)	Not used in this profile
supportingInformation		0..*	Reference(Resource)	Not used in this profile
effective[x]	O	1..1	Period	Start and end time of administration Obligations Actor SHALL:populate Creator (Onconova) SHOULD:persist Consumer (Onconova)
performer		0..*	BackboneElement	Not used in this profile
reasonCode		0..*	CodeableConcept	Not used in this profile
reasonReference	O	1..*	Reference(Primary Cancer Condition Profile | Secondary Cancer Condition Profile)	The condition(s) that motivated the medication administration Obligations Actor SHALL:populate Creator (Onconova) SHOULD:persist Consumer (Onconova)
request		0..1	Reference(MedicationRequest)	Not used in this profile
dosage	S	0..1	BackboneElement	Details of how medication was taken
Documentation for this format

Terminology Bindings (Differential)

Path	Status	Usage	ValueSet	Version	Source
MedicationAdministration.​extension:treatmentIntent.​value[x]	Base	required	Treatment Intents Value Set	📦0.2.0	This IG
MedicationAdministration.​statusReason	Base	required	Treatment Termination Reasons Value Set	📦0.2.0	This IG
MedicationAdministration.​medication[x]	Base	required	Antineoplastic Agents Value Set	📦0.2.0	This IG

Constraints

Id	Grade	Path(s)	Description	Expression
o-med-req-1	error	MedicationAdministration	The subject element is required and must be provided.	subject.exists()
o-med-req-2	error	MedicationAdministration	The effectivePeriod element is required and must be provided.	effectivePeriod.exists()
o-med-req-3	error	MedicationAdministration	The treatmentIntent extension is required and must be provided.	extension('http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-procedure-intent').exists()
o-med-req-4	error	MedicationAdministration	The medicationCodeableConcept element is required and must be provided.	medicationCodeableConcept.exists() and medicationCodeableConcept.coding.exists()

Name	Flags	Card.	Type	Description & Constraints    Filter: Bindings Constraints Obligations
MedicationAdministration	C	0..*	CancerRelatedMedicationAdministration	Administration of medication to a patient Constraints: mcode-reason-required, termination-reason-code-invariant, termination-reason-invariant, o-med-req-1, o-med-req-2, o-med-req-3, o-med-req-4
id	Σ	0..1	id	Logical id of this artifact
meta	Σ	0..1	Meta	Metadata about the resource
implicitRules	?!Σ	0..1	uri	A set of rules under which this content was created
language		0..1	code	Language of the resource content Binding: CommonLanguages (preferred): A human language. Additional Bindings Purpose AllLanguages Max Binding
text		0..1	Narrative	Text summary of the resource, for human interpretation This profile does not constrain the narrative in regard to content, language, or traceability to data elements
contained		0..*	Resource	Contained, inline Resources
Slices for extension	S	1..*	Extension	Extension Slice: Unordered, Open by value:url
extension:treatmentIntent	SO	1..1	(Complex)	Procedure Intent Extension URL: http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-procedure-intent Obligations Actor SHALL:populate Creator (Onconova) SHOULD:persist Consumer (Onconova) SHOULD:populate-if-known Creator (Onconova) SHOULD:persist Consumer (Onconova)
id		0..1	string	Unique id for inter-element referencing
extension		0..0		Extension Slice: Unordered, Open by value:url
url		1..1	uri	"http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-procedure-intent"
value[x]		1..1	CodeableConcept	Value of extension Binding: Treatment Intents Value Set (required)
extension:normalizationBasis		0..1	CodeableConcept	Not used in this profile URL: http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-normalization-basis Binding: Normalization Basis Value Set (required)
extension:combinedWith	SO	0..*	Reference(Medication Administration Profile)	Other medication administered in combination URL: http://onconova.github.io/fhir/StructureDefinition/onconova-ext-medication-administration-combined-with Obligations Actor SHALL:populate-if-known Creator (Onconova) SHOULD:persist Consumer (Onconova)
extension:cycles	SO	0..1	integer	Total number of cycles for this medication URL: http://onconova.github.io/fhir/StructureDefinition/onconova-ext-medication-administration-cycles Obligations Actor SHALL:populate Creator (Onconova) SHOULD:persist Consumer (Onconova)
extension:therapyLine	SO	0..1	Reference(Therapy Line Profile)	Reference to the therapy line associated with this treatment URL: http://onconova.github.io/fhir/StructureDefinition/onconova-ext-therapy-line-reference Obligations Actor MAY:ignore Creator (Onconova) MAY:persist Consumer (Onconova)
extension:adjunctiveRole	SO	0..1	CodeableConcept	Role of this medication in the overall treatment plan URL: http://onconova.github.io/fhir/StructureDefinition/onconova-ext-medication-administration-adjunctive-role Binding: Adjunctive Therapy Roles Value Set (required) Obligations Actor SHALL:populate-if-known Creator (Onconova) SHOULD:persist Consumer (Onconova)
extension:isPrimaryTherapy	SO	0..1	boolean	Indicates if this medication is the primary therapy within a therapy line URL: http://onconova.github.io/fhir/StructureDefinition/onconova-ext-medication-administration-is-primary-therapy Obligations Actor MAY:ignore Creator (Onconova) MAY:persist Consumer (Onconova)
modifierExtension	?!	0..*	Extension	Extensions that cannot be ignored
identifier		0..*	Identifier	External identifier
instantiates	Σ	0..*	uri	Instantiates protocol or definition
partOf	Σ	0..*	Reference(MedicationAdministration | Procedure)	Not used in this profile
status	?!SΣ	1..1	code	Not used in this profile Binding: MedicationAdministration Status Codes (required): A set of codes indicating the current status of a MedicationAdministration.
statusReason	SO	1..1	CodeableConcept	Reason administration not performed Binding: Treatment Termination Reasons Value Set (required) Obligations Actor SHOULD:populate-if-known Creator (Onconova) SHOULD:persist Consumer (Onconova)
category		0..1	CodeableConcept	Type of medication usage Binding: MedicationAdministration Category Codes (preferred): A coded concept describing where the medication administered is expected to occur.
medication[x]	SOΣ	1..1	CodeableConcept	What was administered Binding: Antineoplastic Agents Value Set (required) Obligations Actor SHALL:populate Creator (Onconova) SHOULD:persist Consumer (Onconova)
subject	SOΣ	1..1	Reference(Cancer Patient Profile)	Who received medication Obligations Actor SHALL:populate Creator (Onconova) SHOULD:persist Consumer (Onconova)
context		0..1	Reference(Encounter | EpisodeOfCare)	Not used in this profile
supportingInformation		0..*	Reference(Resource)	Not used in this profile
effective[x]	SOΣ	1..1	Period	Start and end time of administration Obligations Actor SHALL:populate Creator (Onconova) SHOULD:persist Consumer (Onconova)
performer	Σ	0..*	BackboneElement	Not used in this profile
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
function		0..1	CodeableConcept	Type of performance Binding: MedicationAdministration Performer Function Codes (example): A code describing the role an individual played in administering the medication.
actor	Σ	1..1	Reference(Practitioner | PractitionerRole | Patient | RelatedPerson | Device)	Who performed the medication administration
reasonCode	S	0..*	CodeableConcept	Not used in this profile Binding: Cancer Disorder Value Set (extensible)
reasonReference	SO	1..*	Reference(Primary Cancer Condition Profile | Secondary Cancer Condition Profile)	The condition(s) that motivated the medication administration Obligations Actor SHALL:populate Creator (Onconova) SHOULD:persist Consumer (Onconova)
request		0..1	Reference(MedicationRequest)	Not used in this profile
device		0..*	Reference(Device)	Device used to administer
note		0..*	Annotation	Information about the administration
dosage	SC	0..1	BackboneElement	Details of how medication was taken Constraints: mad-1
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
text		0..1	string	Free text dosage instructions e.g. SIG
site		0..1	CodeableConcept	Body site administered to Binding: SNOMEDCTAnatomicalStructureForAdministrationSiteCodes (example): A coded concept describing the site location the medicine enters into or onto the body.
route		0..1	CodeableConcept	Path of substance into body Binding: SNOMEDCTRouteCodes (example): A coded concept describing the route or physiological path of administration of a therapeutic agent into or onto the body of a subject.
method		0..1	CodeableConcept	How drug was administered Binding: SNOMEDCTAdministrationMethodCodes (example): A coded concept describing the technique by which the medicine is administered.
dose		0..1	SimpleQuantity	Amount of medication per dose
rate[x]		0..1		Dose quantity per unit of time
rateRatio			Ratio
rateQuantity			Quantity(SimpleQuantity)
eventHistory		0..*	Reference(Provenance)	A list of events of interest in the lifecycle
Documentation for this format

Terminology Bindings

Path	Status	Usage	ValueSet	Version	Source
MedicationAdministration.​language	Base	preferred	Common Languages	📦4.0.1	FHIR Std.
MedicationAdministration.​extension:treatmentIntent.​value[x]	Base	required	Treatment Intents Value Set	📦0.2.0	This IG
MedicationAdministration.​status	Base	required	Medication administration status codes	📍4.0.1	FHIR Std.
MedicationAdministration.​statusReason	Base	required	Treatment Termination Reasons Value Set	📦0.2.0	This IG
MedicationAdministration.​category	Base	preferred	Medication administration category codes	📦4.0.1	FHIR Std.
MedicationAdministration.​medication[x]	Base	required	Antineoplastic Agents Value Set	📦0.2.0	This IG
MedicationAdministration.​performer.function	Base	example	Medication administration performer function codes	📦4.0.1	FHIR Std.
MedicationAdministration.​reasonCode	Base	extensible	Cancer Disorder Value Set	📦4.0.0	minimal Common Oncology Data Elements v4.0
MedicationAdministration.​dosage.site	Base	example	SNOMED CT Anatomical Structure for Administration Site Codes	📦4.0.1	FHIR Std.
MedicationAdministration.​dosage.route	Base	example	SNOMED CT Route Codes	📦4.0.1	FHIR Std.
MedicationAdministration.​dosage.method	Base	example	SNOMED CT Administration Method Codes	📦4.0.1	FHIR Std.

Constraints

Id	Grade	Path(s)	Description	Expression
dom-2	error	MedicationAdministration	If the resource is contained in another resource, it SHALL NOT contain nested Resources	contained.contained.empty()
dom-3	error	MedicationAdministration	If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource	contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().as(canonical) | %resource.descendants().as(uri) | %resource.descendants().as(url))) or descendants().where(reference = '#').exists() or descendants().where(as(canonical) = '#').exists() or descendants().where(as(canonical) = '#').exists()).not()).trace('unmatched', id).empty()
dom-4	error	MedicationAdministration	If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated	contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()
dom-5	error	MedicationAdministration	If a resource is contained in another resource, it SHALL NOT have a security label	contained.meta.security.empty()
dom-6	best practice	MedicationAdministration	A resource should have narrative for robust management	text.`div`.exists()
ele-1	error	**ALL** elements	All FHIR elements must have a @value or children	hasValue() or (children().count() > id.count())
ext-1	error	**ALL** extensions	Must have either extensions or value[x], not both	extension.exists() != value.exists()
mad-1	error	MedicationAdministration.dosage	SHALL have at least one of dosage.dose or dosage.rate[x]	dose.exists() or rate.exists()
mcode-reason-required	warning	MedicationAdministration	One of reasonCode or reasonReference SHALL be present	reasonCode.exists() or reasonReference.exists()
o-med-req-1	error	MedicationAdministration	The subject element is required and must be provided.	subject.exists()
o-med-req-2	error	MedicationAdministration	The effectivePeriod element is required and must be provided.	effectivePeriod.exists()
o-med-req-3	error	MedicationAdministration	The treatmentIntent extension is required and must be provided.	extension('http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-procedure-intent').exists()
o-med-req-4	error	MedicationAdministration	The medicationCodeableConcept element is required and must be provided.	medicationCodeableConcept.exists() and medicationCodeableConcept.coding.exists()
termination-reason-code-invariant	error	MedicationAdministration	When status is stopped, only certain statusReason values are allowed	status = 'stopped' and statusReason.exists() and statusReason.coding.exists() implies statusReason.coding.exists(system = 'http://snomed.info/sct' and (code = '182992009' or code = '266721009' or code = '407563006' or code = '160932005' or code = '105480006' or code = '184081006' or code = '309846006' or code = '399307001' or code = '419620001' or code = '7058009' or code = '443729008' or code = '77386006'))
termination-reason-invariant	error	MedicationAdministration	Certain statusReason values are allowed only when status is stopped	statusReason.exists() and statusReason.coding.exists( system = 'http://snomed.info/sct' and (code = '182992009' or code = '266721009' or code = '407563006' or code = '160932005' or code = '105480006' or code = '184081006' or code = '309846006' or code = '399307001' or code = '419620001' or code = '7058009' or code = '443729008' or code = '77386006')) implies status = 'stopped'

This structure is derived from CancerRelatedMedicationAdministration

Summary

Mandatory: 4 elements
Must-Support: 1 element

Structures

This structure refers to these other structures:

• Cancer Patient Profile (http://onconova.github.io/fhir/StructureDefinition/onconova-cancer-patient)
• Primary Cancer Condition Profile (http://onconova.github.io/fhir/StructureDefinition/onconova-primary-cancer-condition)
• Secondary Cancer Condition Profile (http://onconova.github.io/fhir/StructureDefinition/onconova-secondary-cancer-condition)

Extensions

This structure refers to these extensions:

• http://onconova.github.io/fhir/StructureDefinition/onconova-ext-medication-administration-combined-with
• http://onconova.github.io/fhir/StructureDefinition/onconova-ext-medication-administration-cycles
• http://onconova.github.io/fhir/StructureDefinition/onconova-ext-therapy-line-reference
• http://onconova.github.io/fhir/StructureDefinition/onconova-ext-medication-administration-adjunctive-role
• http://onconova.github.io/fhir/StructureDefinition/onconova-ext-medication-administration-is-primary-therapy

Key Elements View

Name	Flags	Card.	Type	Description & Constraints    Filter: Bindings Constraints Obligations
MedicationAdministration	C	0..*	CancerRelatedMedicationAdministration	Administration of medication to a patient Constraints: mcode-reason-required, termination-reason-code-invariant, termination-reason-invariant, o-med-req-1, o-med-req-2, o-med-req-3, o-med-req-4
implicitRules	?!Σ	0..1	uri	A set of rules under which this content was created
Slices for extension	S	1..*	Extension	Extension Slice: Unordered, Open by value:url
extension:treatmentIntent	SO	1..1	(Complex)	Procedure Intent Extension URL: http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-procedure-intent Obligations Actor SHALL:populate Creator (Onconova) SHOULD:persist Consumer (Onconova) SHOULD:populate-if-known Creator (Onconova) SHOULD:persist Consumer (Onconova)
extension		0..0		Extension Slice: Unordered, Open by value:url
url		1..1	uri	"http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-procedure-intent"
value[x]		1..1	CodeableConcept	Value of extension Binding: Treatment Intents Value Set (required)
extension:normalizationBasis		0..1	CodeableConcept	Not used in this profile URL: http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-normalization-basis Binding: Normalization Basis Value Set (required)
extension:combinedWith	SO	0..*	Reference(Medication Administration Profile)	Other medication administered in combination URL: http://onconova.github.io/fhir/StructureDefinition/onconova-ext-medication-administration-combined-with Obligations Actor SHALL:populate-if-known Creator (Onconova) SHOULD:persist Consumer (Onconova)
extension:cycles	SO	0..1	integer	Total number of cycles for this medication URL: http://onconova.github.io/fhir/StructureDefinition/onconova-ext-medication-administration-cycles Obligations Actor SHALL:populate Creator (Onconova) SHOULD:persist Consumer (Onconova)
extension:therapyLine	SO	0..1	Reference(Therapy Line Profile)	Reference to the therapy line associated with this treatment URL: http://onconova.github.io/fhir/StructureDefinition/onconova-ext-therapy-line-reference Obligations Actor MAY:ignore Creator (Onconova) MAY:persist Consumer (Onconova)
extension:adjunctiveRole	SO	0..1	CodeableConcept	Role of this medication in the overall treatment plan URL: http://onconova.github.io/fhir/StructureDefinition/onconova-ext-medication-administration-adjunctive-role Binding: Adjunctive Therapy Roles Value Set (required) Obligations Actor SHALL:populate-if-known Creator (Onconova) SHOULD:persist Consumer (Onconova)
extension:isPrimaryTherapy	SO	0..1	boolean	Indicates if this medication is the primary therapy within a therapy line URL: http://onconova.github.io/fhir/StructureDefinition/onconova-ext-medication-administration-is-primary-therapy Obligations Actor MAY:ignore Creator (Onconova) MAY:persist Consumer (Onconova)
modifierExtension	?!	0..*	Extension	Extensions that cannot be ignored
partOf	Σ	0..*	Reference(MedicationAdministration | Procedure)	Not used in this profile
status	?!SΣ	1..1	code	Not used in this profile Binding: MedicationAdministration Status Codes (required): A set of codes indicating the current status of a MedicationAdministration.
statusReason	SO	1..1	CodeableConcept	Reason administration not performed Binding: Treatment Termination Reasons Value Set (required) Obligations Actor SHOULD:populate-if-known Creator (Onconova) SHOULD:persist Consumer (Onconova)
medication[x]	SOΣ	1..1	CodeableConcept	What was administered Binding: Antineoplastic Agents Value Set (required) Obligations Actor SHALL:populate Creator (Onconova) SHOULD:persist Consumer (Onconova)
subject	SOΣ	1..1	Reference(Cancer Patient Profile)	Who received medication Obligations Actor SHALL:populate Creator (Onconova) SHOULD:persist Consumer (Onconova)
context		0..1	Reference(Encounter | EpisodeOfCare)	Not used in this profile
supportingInformation		0..*	Reference(Resource)	Not used in this profile
effective[x]	SOΣ	1..1	Period	Start and end time of administration Obligations Actor SHALL:populate Creator (Onconova) SHOULD:persist Consumer (Onconova)
performer	Σ	0..*	BackboneElement	Not used in this profile
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
actor	Σ	1..1	Reference(Practitioner | PractitionerRole | Patient | RelatedPerson | Device)	Who performed the medication administration
reasonCode	S	0..*	CodeableConcept	Not used in this profile Binding: Cancer Disorder Value Set (extensible)
reasonReference	SO	1..*	Reference(Primary Cancer Condition Profile | Secondary Cancer Condition Profile)	The condition(s) that motivated the medication administration Obligations Actor SHALL:populate Creator (Onconova) SHOULD:persist Consumer (Onconova)
request		0..1	Reference(MedicationRequest)	Not used in this profile
dosage	SC	0..1	BackboneElement	Details of how medication was taken Constraints: mad-1
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
Documentation for this format

Terminology Bindings

Path	Status	Usage	ValueSet	Version	Source
MedicationAdministration.​extension:treatmentIntent.​value[x]	Base	required	Treatment Intents Value Set	📦0.2.0	This IG
MedicationAdministration.​status	Base	required	Medication administration status codes	📍4.0.1	FHIR Std.
MedicationAdministration.​statusReason	Base	required	Treatment Termination Reasons Value Set	📦0.2.0	This IG
MedicationAdministration.​medication[x]	Base	required	Antineoplastic Agents Value Set	📦0.2.0	This IG
MedicationAdministration.​reasonCode	Base	extensible	Cancer Disorder Value Set	📦4.0.0	minimal Common Oncology Data Elements v4.0

Constraints

Id	Grade	Path(s)	Description	Expression
dom-2	error	MedicationAdministration	If the resource is contained in another resource, it SHALL NOT contain nested Resources	contained.contained.empty()
dom-3	error	MedicationAdministration	If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource	contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().as(canonical) | %resource.descendants().as(uri) | %resource.descendants().as(url))) or descendants().where(reference = '#').exists() or descendants().where(as(canonical) = '#').exists() or descendants().where(as(canonical) = '#').exists()).not()).trace('unmatched', id).empty()
dom-4	error	MedicationAdministration	If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated	contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()
dom-5	error	MedicationAdministration	If a resource is contained in another resource, it SHALL NOT have a security label	contained.meta.security.empty()
dom-6	best practice	MedicationAdministration	A resource should have narrative for robust management	text.`div`.exists()
ele-1	error	**ALL** elements	All FHIR elements must have a @value or children	hasValue() or (children().count() > id.count())
ext-1	error	**ALL** extensions	Must have either extensions or value[x], not both	extension.exists() != value.exists()
mad-1	error	MedicationAdministration.dosage	SHALL have at least one of dosage.dose or dosage.rate[x]	dose.exists() or rate.exists()
mcode-reason-required	warning	MedicationAdministration	One of reasonCode or reasonReference SHALL be present	reasonCode.exists() or reasonReference.exists()
o-med-req-1	error	MedicationAdministration	The subject element is required and must be provided.	subject.exists()
o-med-req-2	error	MedicationAdministration	The effectivePeriod element is required and must be provided.	effectivePeriod.exists()
o-med-req-3	error	MedicationAdministration	The treatmentIntent extension is required and must be provided.	extension('http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-procedure-intent').exists()
o-med-req-4	error	MedicationAdministration	The medicationCodeableConcept element is required and must be provided.	medicationCodeableConcept.exists() and medicationCodeableConcept.coding.exists()
termination-reason-code-invariant	error	MedicationAdministration	When status is stopped, only certain statusReason values are allowed	status = 'stopped' and statusReason.exists() and statusReason.coding.exists() implies statusReason.coding.exists(system = 'http://snomed.info/sct' and (code = '182992009' or code = '266721009' or code = '407563006' or code = '160932005' or code = '105480006' or code = '184081006' or code = '309846006' or code = '399307001' or code = '419620001' or code = '7058009' or code = '443729008' or code = '77386006'))
termination-reason-invariant	error	MedicationAdministration	Certain statusReason values are allowed only when status is stopped	statusReason.exists() and statusReason.coding.exists( system = 'http://snomed.info/sct' and (code = '182992009' or code = '266721009' or code = '407563006' or code = '160932005' or code = '105480006' or code = '184081006' or code = '309846006' or code = '399307001' or code = '419620001' or code = '7058009' or code = '443729008' or code = '77386006')) implies status = 'stopped'

Differential View

This structure is derived from CancerRelatedMedicationAdministration

Name	Flags	Card.	Type	Description & Constraints    Filter: Bindings Constraints Obligations
MedicationAdministration	C	0..*	CancerRelatedMedicationAdministration	Administration of medication to a patient Constraints: o-med-req-1, o-med-req-2, o-med-req-3, o-med-req-4
extension		1..*	Extension	Extension
Slices for extension				Content/Rules for all slices
extension:treatmentIntent	O	1..1	ProcedureIntent	Procedure Intent Extension Obligations Actor SHALL:populate Creator (Onconova) SHOULD:persist Consumer (Onconova) SHOULD:populate-if-known Creator (Onconova) SHOULD:persist Consumer (Onconova)
value[x]		1..1	CodeableConcept	Value of extension Binding: Treatment Intents Value Set (required)
extension:normalizationBasis		0..1	NormalizationBasis	Not used in this profile
extension:combinedWith	O	0..*	Reference(Medication Administration Profile)	Other medication administered in combination URL: http://onconova.github.io/fhir/StructureDefinition/onconova-ext-medication-administration-combined-with Obligations Actor SHALL:populate-if-known Creator (Onconova) SHOULD:persist Consumer (Onconova)
extension:cycles	O	0..1	integer	Total number of cycles for this medication URL: http://onconova.github.io/fhir/StructureDefinition/onconova-ext-medication-administration-cycles Obligations Actor SHALL:populate Creator (Onconova) SHOULD:persist Consumer (Onconova)
extension:therapyLine	O	0..1	Reference(Therapy Line Profile)	Reference to the therapy line associated with this treatment URL: http://onconova.github.io/fhir/StructureDefinition/onconova-ext-therapy-line-reference Obligations Actor MAY:ignore Creator (Onconova) MAY:persist Consumer (Onconova)
extension:adjunctiveRole	O	0..1	CodeableConcept	Role of this medication in the overall treatment plan URL: http://onconova.github.io/fhir/StructureDefinition/onconova-ext-medication-administration-adjunctive-role Binding: Adjunctive Therapy Roles Value Set (required) Obligations Actor SHALL:populate-if-known Creator (Onconova) SHOULD:persist Consumer (Onconova)
extension:isPrimaryTherapy	O	0..1	boolean	Indicates if this medication is the primary therapy within a therapy line URL: http://onconova.github.io/fhir/StructureDefinition/onconova-ext-medication-administration-is-primary-therapy Obligations Actor MAY:ignore Creator (Onconova) MAY:persist Consumer (Onconova)
partOf		0..*	Reference(MedicationAdministration | Procedure)	Not used in this profile
status		1..1	code	Not used in this profile
statusReason	O	1..1	CodeableConcept	Reason administration not performed Binding: Treatment Termination Reasons Value Set (required) Obligations Actor SHOULD:populate-if-known Creator (Onconova) SHOULD:persist Consumer (Onconova)
medication[x]	O	1..1	CodeableConcept	What was administered Binding: Antineoplastic Agents Value Set (required) Obligations Actor SHALL:populate Creator (Onconova) SHOULD:persist Consumer (Onconova)
subject	O	1..1	Reference(Cancer Patient Profile)	Who received medication Obligations Actor SHALL:populate Creator (Onconova) SHOULD:persist Consumer (Onconova)
context		0..1	Reference(Encounter | EpisodeOfCare)	Not used in this profile
supportingInformation		0..*	Reference(Resource)	Not used in this profile
effective[x]	O	1..1	Period	Start and end time of administration Obligations Actor SHALL:populate Creator (Onconova) SHOULD:persist Consumer (Onconova)
performer		0..*	BackboneElement	Not used in this profile
reasonCode		0..*	CodeableConcept	Not used in this profile
reasonReference	O	1..*	Reference(Primary Cancer Condition Profile | Secondary Cancer Condition Profile)	The condition(s) that motivated the medication administration Obligations Actor SHALL:populate Creator (Onconova) SHOULD:persist Consumer (Onconova)
request		0..1	Reference(MedicationRequest)	Not used in this profile
dosage	S	0..1	BackboneElement	Details of how medication was taken
Documentation for this format

Terminology Bindings (Differential)

Path	Status	Usage	ValueSet	Version	Source
MedicationAdministration.​extension:treatmentIntent.​value[x]	Base	required	Treatment Intents Value Set	📦0.2.0	This IG
MedicationAdministration.​statusReason	Base	required	Treatment Termination Reasons Value Set	📦0.2.0	This IG
MedicationAdministration.​medication[x]	Base	required	Antineoplastic Agents Value Set	📦0.2.0	This IG

Constraints

Id	Grade	Path(s)	Description	Expression
o-med-req-1	error	MedicationAdministration	The subject element is required and must be provided.	subject.exists()
o-med-req-2	error	MedicationAdministration	The effectivePeriod element is required and must be provided.	effectivePeriod.exists()
o-med-req-3	error	MedicationAdministration	The treatmentIntent extension is required and must be provided.	extension('http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-procedure-intent').exists()
o-med-req-4	error	MedicationAdministration	The medicationCodeableConcept element is required and must be provided.	medicationCodeableConcept.exists() and medicationCodeableConcept.coding.exists()

Snapshot View

Name	Flags	Card.	Type	Description & Constraints    Filter: Bindings Constraints Obligations
MedicationAdministration	C	0..*	CancerRelatedMedicationAdministration	Administration of medication to a patient Constraints: mcode-reason-required, termination-reason-code-invariant, termination-reason-invariant, o-med-req-1, o-med-req-2, o-med-req-3, o-med-req-4
id	Σ	0..1	id	Logical id of this artifact
meta	Σ	0..1	Meta	Metadata about the resource
implicitRules	?!Σ	0..1	uri	A set of rules under which this content was created
language		0..1	code	Language of the resource content Binding: CommonLanguages (preferred): A human language. Additional Bindings Purpose AllLanguages Max Binding
text		0..1	Narrative	Text summary of the resource, for human interpretation This profile does not constrain the narrative in regard to content, language, or traceability to data elements
contained		0..*	Resource	Contained, inline Resources
Slices for extension	S	1..*	Extension	Extension Slice: Unordered, Open by value:url
extension:treatmentIntent	SO	1..1	(Complex)	Procedure Intent Extension URL: http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-procedure-intent Obligations Actor SHALL:populate Creator (Onconova) SHOULD:persist Consumer (Onconova) SHOULD:populate-if-known Creator (Onconova) SHOULD:persist Consumer (Onconova)
id		0..1	string	Unique id for inter-element referencing
extension		0..0		Extension Slice: Unordered, Open by value:url
url		1..1	uri	"http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-procedure-intent"
value[x]		1..1	CodeableConcept	Value of extension Binding: Treatment Intents Value Set (required)
extension:normalizationBasis		0..1	CodeableConcept	Not used in this profile URL: http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-normalization-basis Binding: Normalization Basis Value Set (required)
extension:combinedWith	SO	0..*	Reference(Medication Administration Profile)	Other medication administered in combination URL: http://onconova.github.io/fhir/StructureDefinition/onconova-ext-medication-administration-combined-with Obligations Actor SHALL:populate-if-known Creator (Onconova) SHOULD:persist Consumer (Onconova)
extension:cycles	SO	0..1	integer	Total number of cycles for this medication URL: http://onconova.github.io/fhir/StructureDefinition/onconova-ext-medication-administration-cycles Obligations Actor SHALL:populate Creator (Onconova) SHOULD:persist Consumer (Onconova)
extension:therapyLine	SO	0..1	Reference(Therapy Line Profile)	Reference to the therapy line associated with this treatment URL: http://onconova.github.io/fhir/StructureDefinition/onconova-ext-therapy-line-reference Obligations Actor MAY:ignore Creator (Onconova) MAY:persist Consumer (Onconova)
extension:adjunctiveRole	SO	0..1	CodeableConcept	Role of this medication in the overall treatment plan URL: http://onconova.github.io/fhir/StructureDefinition/onconova-ext-medication-administration-adjunctive-role Binding: Adjunctive Therapy Roles Value Set (required) Obligations Actor SHALL:populate-if-known Creator (Onconova) SHOULD:persist Consumer (Onconova)
extension:isPrimaryTherapy	SO	0..1	boolean	Indicates if this medication is the primary therapy within a therapy line URL: http://onconova.github.io/fhir/StructureDefinition/onconova-ext-medication-administration-is-primary-therapy Obligations Actor MAY:ignore Creator (Onconova) MAY:persist Consumer (Onconova)
modifierExtension	?!	0..*	Extension	Extensions that cannot be ignored
identifier		0..*	Identifier	External identifier
instantiates	Σ	0..*	uri	Instantiates protocol or definition
partOf	Σ	0..*	Reference(MedicationAdministration | Procedure)	Not used in this profile
status	?!SΣ	1..1	code	Not used in this profile Binding: MedicationAdministration Status Codes (required): A set of codes indicating the current status of a MedicationAdministration.
statusReason	SO	1..1	CodeableConcept	Reason administration not performed Binding: Treatment Termination Reasons Value Set (required) Obligations Actor SHOULD:populate-if-known Creator (Onconova) SHOULD:persist Consumer (Onconova)
category		0..1	CodeableConcept	Type of medication usage Binding: MedicationAdministration Category Codes (preferred): A coded concept describing where the medication administered is expected to occur.
medication[x]	SOΣ	1..1	CodeableConcept	What was administered Binding: Antineoplastic Agents Value Set (required) Obligations Actor SHALL:populate Creator (Onconova) SHOULD:persist Consumer (Onconova)
subject	SOΣ	1..1	Reference(Cancer Patient Profile)	Who received medication Obligations Actor SHALL:populate Creator (Onconova) SHOULD:persist Consumer (Onconova)
context		0..1	Reference(Encounter | EpisodeOfCare)	Not used in this profile
supportingInformation		0..*	Reference(Resource)	Not used in this profile
effective[x]	SOΣ	1..1	Period	Start and end time of administration Obligations Actor SHALL:populate Creator (Onconova) SHOULD:persist Consumer (Onconova)
performer	Σ	0..*	BackboneElement	Not used in this profile
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
function		0..1	CodeableConcept	Type of performance Binding: MedicationAdministration Performer Function Codes (example): A code describing the role an individual played in administering the medication.
actor	Σ	1..1	Reference(Practitioner | PractitionerRole | Patient | RelatedPerson | Device)	Who performed the medication administration
reasonCode	S	0..*	CodeableConcept	Not used in this profile Binding: Cancer Disorder Value Set (extensible)
reasonReference	SO	1..*	Reference(Primary Cancer Condition Profile | Secondary Cancer Condition Profile)	The condition(s) that motivated the medication administration Obligations Actor SHALL:populate Creator (Onconova) SHOULD:persist Consumer (Onconova)
request		0..1	Reference(MedicationRequest)	Not used in this profile
device		0..*	Reference(Device)	Device used to administer
note		0..*	Annotation	Information about the administration
dosage	SC	0..1	BackboneElement	Details of how medication was taken Constraints: mad-1
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
text		0..1	string	Free text dosage instructions e.g. SIG
site		0..1	CodeableConcept	Body site administered to Binding: SNOMEDCTAnatomicalStructureForAdministrationSiteCodes (example): A coded concept describing the site location the medicine enters into or onto the body.
route		0..1	CodeableConcept	Path of substance into body Binding: SNOMEDCTRouteCodes (example): A coded concept describing the route or physiological path of administration of a therapeutic agent into or onto the body of a subject.
method		0..1	CodeableConcept	How drug was administered Binding: SNOMEDCTAdministrationMethodCodes (example): A coded concept describing the technique by which the medicine is administered.
dose		0..1	SimpleQuantity	Amount of medication per dose
rate[x]		0..1		Dose quantity per unit of time
rateRatio			Ratio
rateQuantity			Quantity(SimpleQuantity)
eventHistory		0..*	Reference(Provenance)	A list of events of interest in the lifecycle
Documentation for this format

Terminology Bindings

Path	Status	Usage	ValueSet	Version	Source
MedicationAdministration.​language	Base	preferred	Common Languages	📦4.0.1	FHIR Std.
MedicationAdministration.​extension:treatmentIntent.​value[x]	Base	required	Treatment Intents Value Set	📦0.2.0	This IG
MedicationAdministration.​status	Base	required	Medication administration status codes	📍4.0.1	FHIR Std.
MedicationAdministration.​statusReason	Base	required	Treatment Termination Reasons Value Set	📦0.2.0	This IG
MedicationAdministration.​category	Base	preferred	Medication administration category codes	📦4.0.1	FHIR Std.
MedicationAdministration.​medication[x]	Base	required	Antineoplastic Agents Value Set	📦0.2.0	This IG
MedicationAdministration.​performer.function	Base	example	Medication administration performer function codes	📦4.0.1	FHIR Std.
MedicationAdministration.​reasonCode	Base	extensible	Cancer Disorder Value Set	📦4.0.0	minimal Common Oncology Data Elements v4.0
MedicationAdministration.​dosage.site	Base	example	SNOMED CT Anatomical Structure for Administration Site Codes	📦4.0.1	FHIR Std.
MedicationAdministration.​dosage.route	Base	example	SNOMED CT Route Codes	📦4.0.1	FHIR Std.
MedicationAdministration.​dosage.method	Base	example	SNOMED CT Administration Method Codes	📦4.0.1	FHIR Std.

Constraints

Id	Grade	Path(s)	Description	Expression
dom-2	error	MedicationAdministration	If the resource is contained in another resource, it SHALL NOT contain nested Resources	contained.contained.empty()
dom-3	error	MedicationAdministration	If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource	contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().as(canonical) | %resource.descendants().as(uri) | %resource.descendants().as(url))) or descendants().where(reference = '#').exists() or descendants().where(as(canonical) = '#').exists() or descendants().where(as(canonical) = '#').exists()).not()).trace('unmatched', id).empty()
dom-4	error	MedicationAdministration	If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated	contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()
dom-5	error	MedicationAdministration	If a resource is contained in another resource, it SHALL NOT have a security label	contained.meta.security.empty()
dom-6	best practice	MedicationAdministration	A resource should have narrative for robust management	text.`div`.exists()
ele-1	error	**ALL** elements	All FHIR elements must have a @value or children	hasValue() or (children().count() > id.count())
ext-1	error	**ALL** extensions	Must have either extensions or value[x], not both	extension.exists() != value.exists()
mad-1	error	MedicationAdministration.dosage	SHALL have at least one of dosage.dose or dosage.rate[x]	dose.exists() or rate.exists()
mcode-reason-required	warning	MedicationAdministration	One of reasonCode or reasonReference SHALL be present	reasonCode.exists() or reasonReference.exists()
o-med-req-1	error	MedicationAdministration	The subject element is required and must be provided.	subject.exists()
o-med-req-2	error	MedicationAdministration	The effectivePeriod element is required and must be provided.	effectivePeriod.exists()
o-med-req-3	error	MedicationAdministration	The treatmentIntent extension is required and must be provided.	extension('http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-procedure-intent').exists()
o-med-req-4	error	MedicationAdministration	The medicationCodeableConcept element is required and must be provided.	medicationCodeableConcept.exists() and medicationCodeableConcept.coding.exists()
termination-reason-code-invariant	error	MedicationAdministration	When status is stopped, only certain statusReason values are allowed	status = 'stopped' and statusReason.exists() and statusReason.coding.exists() implies statusReason.coding.exists(system = 'http://snomed.info/sct' and (code = '182992009' or code = '266721009' or code = '407563006' or code = '160932005' or code = '105480006' or code = '184081006' or code = '309846006' or code = '399307001' or code = '419620001' or code = '7058009' or code = '443729008' or code = '77386006'))
termination-reason-invariant	error	MedicationAdministration	Certain statusReason values are allowed only when status is stopped	statusReason.exists() and statusReason.coding.exists( system = 'http://snomed.info/sct' and (code = '182992009' or code = '266721009' or code = '407563006' or code = '160932005' or code = '105480006' or code = '184081006' or code = '309846006' or code = '399307001' or code = '419620001' or code = '7058009' or code = '443729008' or code = '77386006')) implies status = 'stopped'

This structure is derived from CancerRelatedMedicationAdministration

Summary

Mandatory: 4 elements
Must-Support: 1 element

Structures

This structure refers to these other structures:

• Cancer Patient Profile (http://onconova.github.io/fhir/StructureDefinition/onconova-cancer-patient)
• Primary Cancer Condition Profile (http://onconova.github.io/fhir/StructureDefinition/onconova-primary-cancer-condition)
• Secondary Cancer Condition Profile (http://onconova.github.io/fhir/StructureDefinition/onconova-secondary-cancer-condition)

Extensions

This structure refers to these extensions:

• http://onconova.github.io/fhir/StructureDefinition/onconova-ext-medication-administration-combined-with
• http://onconova.github.io/fhir/StructureDefinition/onconova-ext-medication-administration-cycles
• http://onconova.github.io/fhir/StructureDefinition/onconova-ext-therapy-line-reference
• http://onconova.github.io/fhir/StructureDefinition/onconova-ext-medication-administration-adjunctive-role
• http://onconova.github.io/fhir/StructureDefinition/onconova-ext-medication-administration-is-primary-therapy

Other representations of profile: CSV, Excel, Schematron