Onconova Implementation Guide
0.2.0 - ci-build

Onconova Implementation Guide - Local Development build (v0.2.0) built by the FHIR (HL7® FHIR® Standard) Build Tools. See the Directory of published versions

Extension: AdverseEventMitigation - Detailed Descriptions

Active as of 2026-03-18

Definitions for the onconova-ext-adverse-event-mitigation extension.

Guidance on how to interpret the contents of this table can be foundhere

0. Extension
Definition

Details about an action taken to mitigate or manage the adverse event.


Optional Extension Element - found in all resources.

ShortAdverse Event MitigationOptional Extensions Element
Control0..*
This element is affected by the following invariants: ele-1
Is Modifierfalse
Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
drug-mitigation: If the mitigation category is 'Drug', then only mitigation drug must be specified. (extension('category').valueCodeableConcept.coding.code = 'C49158' implies (extension('drug').exists() and extension('procedure').exists().not() and extension('adjustment').exists().not()))
adjustment-mitigation: If the mitigation category is 'Adjustment', then only mitigation adjustment must be specified. (extension('category').valueCodeableConcept.coding.code = 'C49157' implies (extension('adjustment').exists() and extension('procedure').exists().not() and extension('drug').exists().not()))
procedural-mitigation: If the mitigation category is 'Procedure', then only mitigation procedure must be specified. (extension('category').valueCodeableConcept.coding.code = 'C49159' implies (extension('procedure').exists() and extension('adjustment').exists().not() and extension('drug').exists().not()))
ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
2. Extension.extension
Definition

An Extension


May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

ShortExtensionAdditional content defined by implementations
Comments

There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

Control10..*
TypeExtension
Is Modifierfalse
Summaryfalse
Alternate Namesextensions, user content
Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
SlicingThis element introduces a set of slices on Extension.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
  • value @ url
  • 4. Extension.extension:category
    Slice Namecategory
    Definition

    Type of mitigation action taken to address the adverse event.

    ShortMitigation CategoryAdditional content defined by implementations
    Control10..1*
    TypeExtension
    Is Modifierfalse
    Obligations
      ObligationsActor
      SHALL:populateCreator (Onconova)
      SHOULD:persistConsumer (Onconova)
      Summaryfalse
      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
      ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
      6. Extension.extension:category.extension
      Definition

      An Extension


      May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

      ShortExtensionAdditional content defined by implementations
      Comments

      There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

      Control0..0*
      TypeExtension
      Is Modifierfalse
      Summaryfalse
      Alternate Namesextensions, user content
      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
      ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
      SlicingThis element introduces a set of slices on Extension.extension.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
      • value @ url
      • 8. Extension.extension:category.url
        Definition

        Source of the definition for the extension code - a logical name or a URL.

        Shortidentifies the meaning of the extension
        Comments

        The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.

        Control1..1
        Typeuri
        Is Modifierfalse
        XML FormatIn the XML format, this property is represented as an attribute.
        Summaryfalse
        Fixed Valuecategory
        10. Extension.extension:category.value[x]
        Definition

        Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).

        ShortValue of extension
        Control0..1
        BindingThe codes SHALL be taken from For codes, see Adverse Event Mitigation Categories Value Set
        (required to http://onconova.github.io/fhir/ValueSet/onconova-vs-adverse-event-mitigation-categories)
        TypeCodeableConcept, date, Meta, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, ParameterDefinition, dateTime, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, Signature, unsignedInt, time
        [x] NoteSeeChoice of Data Typesfor further information about how to use [x]
        Is Modifierfalse
        Summaryfalse
        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
        12. Extension.extension:adjustment
        Slice Nameadjustment
        Definition

        Details of any adjustments made to the treatment regimen in response to the adverse event.

        ShortTreatment AdjustmentAdditional content defined by implementations
        Control0..1*
        TypeExtension
        Is Modifierfalse
        Obligations
          ObligationsActor
          SHALL:populate-if-knownCreator (Onconova)
          SHOULD:persistConsumer (Onconova)
          Summaryfalse
          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
          ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
          14. Extension.extension:adjustment.extension
          Definition

          An Extension


          May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

          ShortExtensionAdditional content defined by implementations
          Comments

          There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

          Control0..0*
          TypeExtension
          Is Modifierfalse
          Summaryfalse
          Alternate Namesextensions, user content
          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
          ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
          SlicingThis element introduces a set of slices on Extension.extension.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
          • value @ url
          • 16. Extension.extension:adjustment.url
            Definition

            Source of the definition for the extension code - a logical name or a URL.

            Shortidentifies the meaning of the extension
            Comments

            The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.

            Control1..1
            Typeuri
            Is Modifierfalse
            XML FormatIn the XML format, this property is represented as an attribute.
            Summaryfalse
            Fixed Valueadjustment
            18. Extension.extension:adjustment.value[x]
            Definition

            Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).

            ShortValue of extension
            Control0..1
            BindingThe codes SHALL be taken from For codes, see Adverse Event Mitigation Treatment Adjustments Value Set
            (required to http://onconova.github.io/fhir/ValueSet/onconova-vs-adverse-event-mitigation-treatment-adjustments)
            TypeCodeableConcept, date, Meta, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, ParameterDefinition, dateTime, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, Signature, unsignedInt, time
            [x] NoteSeeChoice of Data Typesfor further information about how to use [x]
            Is Modifierfalse
            Summaryfalse
            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
            20. Extension.extension:drug
            Slice Namedrug
            Definition

            Medication administered to mitigate the adverse event.

            ShortMitigation DrugAdditional content defined by implementations
            Control0..1*
            TypeExtension
            Is Modifierfalse
            Obligations
              ObligationsActor
              SHALL:populate-if-knownCreator (Onconova)
              SHOULD:persistConsumer (Onconova)
              Summaryfalse
              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
              ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
              22. Extension.extension:drug.extension
              Definition

              An Extension


              May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

              ShortExtensionAdditional content defined by implementations
              Comments

              There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

              Control0..0*
              TypeExtension
              Is Modifierfalse
              Summaryfalse
              Alternate Namesextensions, user content
              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
              ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
              SlicingThis element introduces a set of slices on Extension.extension.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
              • value @ url
              • 24. Extension.extension:drug.url
                Definition

                Source of the definition for the extension code - a logical name or a URL.

                Shortidentifies the meaning of the extension
                Comments

                The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.

                Control1..1
                Typeuri
                Is Modifierfalse
                XML FormatIn the XML format, this property is represented as an attribute.
                Summaryfalse
                Fixed Valuedrug
                26. Extension.extension:drug.value[x]
                Definition

                Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).

                ShortValue of extension
                Control0..1
                BindingThe codes SHALL be taken from For codes, see Adverse Event Mitigation Drugs Value Set
                (required to http://onconova.github.io/fhir/ValueSet/onconova-vs-adverse-event-mitigation-drugs)
                TypeCodeableConcept, date, Meta, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, ParameterDefinition, dateTime, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, Signature, unsignedInt, time
                [x] NoteSeeChoice of Data Typesfor further information about how to use [x]
                Is Modifierfalse
                Summaryfalse
                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                28. Extension.extension:procedure
                Slice Nameprocedure
                Definition

                Procedure performed to mitigate the adverse event.

                ShortMitigation ProcedureAdditional content defined by implementations
                Control0..1*
                TypeExtension
                Is Modifierfalse
                Obligations
                  ObligationsActor
                  SHALL:populate-if-knownCreator (Onconova)
                  SHOULD:persistConsumer (Onconova)
                  Summaryfalse
                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                  ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                  30. Extension.extension:procedure.extension
                  Definition

                  An Extension


                  May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                  ShortExtensionAdditional content defined by implementations
                  Comments

                  There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                  Control0..0*
                  TypeExtension
                  Is Modifierfalse
                  Summaryfalse
                  Alternate Namesextensions, user content
                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                  ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                  SlicingThis element introduces a set of slices on Extension.extension.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                  • value @ url
                  • 32. Extension.extension:procedure.url
                    Definition

                    Source of the definition for the extension code - a logical name or a URL.

                    Shortidentifies the meaning of the extension
                    Comments

                    The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.

                    Control1..1
                    Typeuri
                    Is Modifierfalse
                    XML FormatIn the XML format, this property is represented as an attribute.
                    Summaryfalse
                    Fixed Valueprocedure
                    34. Extension.extension:procedure.value[x]
                    Definition

                    Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).

                    ShortValue of extension
                    Control0..1
                    BindingThe codes SHALL be taken from For codes, see Adverse Event Mitigation Procedures Value Set
                    (required to http://onconova.github.io/fhir/ValueSet/onconova-vs-adverse-event-mitigation-procedures)
                    TypeCodeableConcept, date, Meta, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, ParameterDefinition, dateTime, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, Signature, unsignedInt, time
                    [x] NoteSeeChoice of Data Typesfor further information about how to use [x]
                    Is Modifierfalse
                    Summaryfalse
                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                    36. Extension.extension:management
                    Slice Namemanagement
                    Definition

                    Management strategies employed to address the adverse event.

                    ShortManagementAdditional content defined by implementations
                    Control0..1*
                    TypeExtension
                    Is Modifierfalse
                    Obligations
                      ObligationsActor
                      SHOULD:populate-if-knownCreator (Onconova)
                      MAY:persistConsumer (Onconova)
                      Summaryfalse
                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                      ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                      38. Extension.extension:management.extension
                      Definition

                      An Extension


                      May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                      ShortExtensionAdditional content defined by implementations
                      Comments

                      There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                      Control0..0*
                      TypeExtension
                      Is Modifierfalse
                      Summaryfalse
                      Alternate Namesextensions, user content
                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                      ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                      SlicingThis element introduces a set of slices on Extension.extension.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                      • value @ url
                      • 40. Extension.extension:management.url
                        Definition

                        Source of the definition for the extension code - a logical name or a URL.

                        Shortidentifies the meaning of the extension
                        Comments

                        The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.

                        Control1..1
                        Typeuri
                        Is Modifierfalse
                        XML FormatIn the XML format, this property is represented as an attribute.
                        Summaryfalse
                        Fixed Valuemanagement
                        42. Extension.extension:management.value[x]
                        Definition

                        Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).

                        ShortValue of extension
                        Control0..1
                        BindingThe codes SHALL be taken from For codes, see Adverse Event Mitigation Managements Value Set
                        (required to http://onconova.github.io/fhir/ValueSet/onconova-vs-adverse-event-mitigation-managements)
                        TypeCodeableConcept, date, Meta, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, ParameterDefinition, dateTime, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, Signature, unsignedInt, time
                        [x] NoteSeeChoice of Data Typesfor further information about how to use [x]
                        Is Modifierfalse
                        Summaryfalse
                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                        44. Extension.url
                        Definition

                        Source of the definition for the extension code - a logical name or a URL.

                        Shortidentifies the meaning of the extension
                        Comments

                        The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.

                        Control1..1
                        Typeuri
                        Is Modifierfalse
                        XML FormatIn the XML format, this property is represented as an attribute.
                        Summaryfalse
                        Fixed Valuehttp://onconova.github.io/fhir/StructureDefinition/onconova-ext-adverse-event-mitigation
                        46. Extension.value[x]
                        Definition

                        Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).

                        ShortValue of extension
                        Control0..01
                        TypeChoice of: base64Binary, boolean, canonical, code, date, dateTime, decimal, id, instant, integer, markdown, oid, positiveInt, string, time, unsignedInt, uri, url, uuid, Address, Age, Annotation, Attachment, CodeableConcept, Coding, ContactPoint, Count, Distance, Duration, HumanName, Identifier, Money, Period, Quantity, Range, Ratio, Reference, SampledData, Signature, Timing, ContactDetail, Contributor, DataRequirement, Expression, ParameterDefinition, RelatedArtifact, TriggerDefinition, UsageContext, Dosage, Meta
                        Is Modifierfalse
                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                        Summaryfalse
                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))

                        Guidance on how to interpret the contents of this table can be foundhere

                        0. Extension
                        Definition

                        Details about an action taken to mitigate or manage the adverse event.

                        ShortAdverse Event Mitigation
                        Invariantsdrug-mitigation: If the mitigation category is 'Drug', then only mitigation drug must be specified. (extension('category').valueCodeableConcept.coding.code = 'C49158' implies (extension('drug').exists() and extension('procedure').exists().not() and extension('adjustment').exists().not()))
                        adjustment-mitigation: If the mitigation category is 'Adjustment', then only mitigation adjustment must be specified. (extension('category').valueCodeableConcept.coding.code = 'C49157' implies (extension('adjustment').exists() and extension('procedure').exists().not() and extension('drug').exists().not()))
                        procedural-mitigation: If the mitigation category is 'Procedure', then only mitigation procedure must be specified. (extension('category').valueCodeableConcept.coding.code = 'C49159' implies (extension('procedure').exists() and extension('adjustment').exists().not() and extension('drug').exists().not()))
                        2. Extension.extension
                        Control1..?
                        4. Extension.extension:category
                        Slice Namecategory
                        Definition

                        Type of mitigation action taken to address the adverse event.

                        ShortMitigation Category
                        Control1..1
                        Obligations
                          ObligationsActor
                          SHALL:populateCreator (Onconova)
                          SHOULD:persistConsumer (Onconova)
                          6. Extension.extension:category.extension
                          Control0..0
                          8. Extension.extension:category.url
                          Fixed Valuecategory
                          10. Extension.extension:category.value[x]
                          BindingThe codes SHALL be taken from Adverse Event Mitigation Categories Value Set
                          (required to http://onconova.github.io/fhir/ValueSet/onconova-vs-adverse-event-mitigation-categories)
                          TypeCodeableConcept
                          [x] NoteSeeChoice of Data Typesfor further information about how to use [x]
                          12. Extension.extension:adjustment
                          Slice Nameadjustment
                          Definition

                          Details of any adjustments made to the treatment regimen in response to the adverse event.

                          ShortTreatment Adjustment
                          Control0..1
                          Obligations
                            ObligationsActor
                            SHALL:populate-if-knownCreator (Onconova)
                            SHOULD:persistConsumer (Onconova)
                            14. Extension.extension:adjustment.extension
                            Control0..0
                            16. Extension.extension:adjustment.url
                            Fixed Valueadjustment
                            18. Extension.extension:adjustment.value[x]
                            BindingThe codes SHALL be taken from Adverse Event Mitigation Treatment Adjustments Value Set
                            (required to http://onconova.github.io/fhir/ValueSet/onconova-vs-adverse-event-mitigation-treatment-adjustments)
                            TypeCodeableConcept
                            [x] NoteSeeChoice of Data Typesfor further information about how to use [x]
                            20. Extension.extension:drug
                            Slice Namedrug
                            Definition

                            Medication administered to mitigate the adverse event.

                            ShortMitigation Drug
                            Control0..1
                            Obligations
                              ObligationsActor
                              SHALL:populate-if-knownCreator (Onconova)
                              SHOULD:persistConsumer (Onconova)
                              22. Extension.extension:drug.extension
                              Control0..0
                              24. Extension.extension:drug.url
                              Fixed Valuedrug
                              26. Extension.extension:drug.value[x]
                              BindingThe codes SHALL be taken from Adverse Event Mitigation Drugs Value Set
                              (required to http://onconova.github.io/fhir/ValueSet/onconova-vs-adverse-event-mitigation-drugs)
                              TypeCodeableConcept
                              [x] NoteSeeChoice of Data Typesfor further information about how to use [x]
                              28. Extension.extension:procedure
                              Slice Nameprocedure
                              Definition

                              Procedure performed to mitigate the adverse event.

                              ShortMitigation Procedure
                              Control0..1
                              Obligations
                                ObligationsActor
                                SHALL:populate-if-knownCreator (Onconova)
                                SHOULD:persistConsumer (Onconova)
                                30. Extension.extension:procedure.extension
                                Control0..0
                                32. Extension.extension:procedure.url
                                Fixed Valueprocedure
                                34. Extension.extension:procedure.value[x]
                                BindingThe codes SHALL be taken from Adverse Event Mitigation Procedures Value Set
                                (required to http://onconova.github.io/fhir/ValueSet/onconova-vs-adverse-event-mitigation-procedures)
                                TypeCodeableConcept
                                [x] NoteSeeChoice of Data Typesfor further information about how to use [x]
                                36. Extension.extension:management
                                Slice Namemanagement
                                Definition

                                Management strategies employed to address the adverse event.

                                ShortManagement
                                Control0..1
                                Obligations
                                  ObligationsActor
                                  SHOULD:populate-if-knownCreator (Onconova)
                                  MAY:persistConsumer (Onconova)
                                  38. Extension.extension:management.extension
                                  Control0..0
                                  40. Extension.extension:management.url
                                  Fixed Valuemanagement
                                  42. Extension.extension:management.value[x]
                                  BindingThe codes SHALL be taken from Adverse Event Mitigation Managements Value Set
                                  (required to http://onconova.github.io/fhir/ValueSet/onconova-vs-adverse-event-mitigation-managements)
                                  TypeCodeableConcept
                                  [x] NoteSeeChoice of Data Typesfor further information about how to use [x]
                                  44. Extension.url
                                  Fixed Valuehttp://onconova.github.io/fhir/StructureDefinition/onconova-ext-adverse-event-mitigation
                                  46. Extension.value[x]
                                  Control0..0

                                  Guidance on how to interpret the contents of this table can be foundhere

                                  0. Extension
                                  Definition

                                  Details about an action taken to mitigate or manage the adverse event.

                                  ShortAdverse Event Mitigation
                                  Control0..*
                                  This element is affected by the following invariants: ele-1
                                  Is Modifierfalse
                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                  ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                  drug-mitigation: If the mitigation category is 'Drug', then only mitigation drug must be specified. (extension('category').valueCodeableConcept.coding.code = 'C49158' implies (extension('drug').exists() and extension('procedure').exists().not() and extension('adjustment').exists().not()))
                                  adjustment-mitigation: If the mitigation category is 'Adjustment', then only mitigation adjustment must be specified. (extension('category').valueCodeableConcept.coding.code = 'C49157' implies (extension('adjustment').exists() and extension('procedure').exists().not() and extension('drug').exists().not()))
                                  procedural-mitigation: If the mitigation category is 'Procedure', then only mitigation procedure must be specified. (extension('category').valueCodeableConcept.coding.code = 'C49159' implies (extension('procedure').exists() and extension('adjustment').exists().not() and extension('drug').exists().not()))
                                  2. Extension.id
                                  Definition

                                  Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                  ShortUnique id for inter-element referencing
                                  Control0..1
                                  Typestring
                                  Is Modifierfalse
                                  XML FormatIn the XML format, this property is represented as an attribute.
                                  Summaryfalse
                                  4. Extension.extension
                                  Definition

                                  An Extension

                                  ShortExtension
                                  Control1..*
                                  TypeExtension
                                  Is Modifierfalse
                                  Summaryfalse
                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                  ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                  SlicingThis element introduces a set of slices on Extension.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                  • value @ url
                                  • 6. Extension.extension:category
                                    Slice Namecategory
                                    Definition

                                    Type of mitigation action taken to address the adverse event.

                                    ShortMitigation Category
                                    Control1..1
                                    TypeExtension
                                    Is Modifierfalse
                                    Obligations
                                      ObligationsActor
                                      SHALL:populateCreator (Onconova)
                                      SHOULD:persistConsumer (Onconova)
                                      Summaryfalse
                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                      ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                      8. Extension.extension:category.id
                                      Definition

                                      Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                      ShortUnique id for inter-element referencing
                                      Control0..1
                                      Typestring
                                      Is Modifierfalse
                                      XML FormatIn the XML format, this property is represented as an attribute.
                                      Summaryfalse
                                      10. Extension.extension:category.extension
                                      Definition

                                      An Extension

                                      ShortExtension
                                      Control0..0
                                      TypeExtension
                                      Is Modifierfalse
                                      Summaryfalse
                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                      ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                      SlicingThis element introduces a set of slices on Extension.extension.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                      • value @ url
                                      • 12. Extension.extension:category.url
                                        Definition

                                        Source of the definition for the extension code - a logical name or a URL.

                                        Shortidentifies the meaning of the extension
                                        Comments

                                        The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.

                                        Control1..1
                                        Typeuri
                                        Is Modifierfalse
                                        XML FormatIn the XML format, this property is represented as an attribute.
                                        Summaryfalse
                                        Fixed Valuecategory
                                        14. Extension.extension:category.value[x]
                                        Definition

                                        Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).

                                        ShortValue of extension
                                        Control0..1
                                        BindingThe codes SHALL be taken from Adverse Event Mitigation Categories Value Set
                                        (required to http://onconova.github.io/fhir/ValueSet/onconova-vs-adverse-event-mitigation-categories)
                                        TypeCodeableConcept
                                        [x] NoteSeeChoice of Data Typesfor further information about how to use [x]
                                        Is Modifierfalse
                                        Summaryfalse
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        16. Extension.extension:adjustment
                                        Slice Nameadjustment
                                        Definition

                                        Details of any adjustments made to the treatment regimen in response to the adverse event.

                                        ShortTreatment Adjustment
                                        Control0..1
                                        TypeExtension
                                        Is Modifierfalse
                                        Obligations
                                          ObligationsActor
                                          SHALL:populate-if-knownCreator (Onconova)
                                          SHOULD:persistConsumer (Onconova)
                                          Summaryfalse
                                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                          ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                          18. Extension.extension:adjustment.id
                                          Definition

                                          Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                          ShortUnique id for inter-element referencing
                                          Control0..1
                                          Typestring
                                          Is Modifierfalse
                                          XML FormatIn the XML format, this property is represented as an attribute.
                                          Summaryfalse
                                          20. Extension.extension:adjustment.extension
                                          Definition

                                          An Extension

                                          ShortExtension
                                          Control0..0
                                          TypeExtension
                                          Is Modifierfalse
                                          Summaryfalse
                                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                          ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                          SlicingThis element introduces a set of slices on Extension.extension.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                          • value @ url
                                          • 22. Extension.extension:adjustment.url
                                            Definition

                                            Source of the definition for the extension code - a logical name or a URL.

                                            Shortidentifies the meaning of the extension
                                            Comments

                                            The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.

                                            Control1..1
                                            Typeuri
                                            Is Modifierfalse
                                            XML FormatIn the XML format, this property is represented as an attribute.
                                            Summaryfalse
                                            Fixed Valueadjustment
                                            24. Extension.extension:adjustment.value[x]
                                            Definition

                                            Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).

                                            ShortValue of extension
                                            Control0..1
                                            BindingThe codes SHALL be taken from Adverse Event Mitigation Treatment Adjustments Value Set
                                            (required to http://onconova.github.io/fhir/ValueSet/onconova-vs-adverse-event-mitigation-treatment-adjustments)
                                            TypeCodeableConcept
                                            [x] NoteSeeChoice of Data Typesfor further information about how to use [x]
                                            Is Modifierfalse
                                            Summaryfalse
                                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                            26. Extension.extension:drug
                                            Slice Namedrug
                                            Definition

                                            Medication administered to mitigate the adverse event.

                                            ShortMitigation Drug
                                            Control0..1
                                            TypeExtension
                                            Is Modifierfalse
                                            Obligations
                                              ObligationsActor
                                              SHALL:populate-if-knownCreator (Onconova)
                                              SHOULD:persistConsumer (Onconova)
                                              Summaryfalse
                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                              ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                              28. Extension.extension:drug.id
                                              Definition

                                              Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                              ShortUnique id for inter-element referencing
                                              Control0..1
                                              Typestring
                                              Is Modifierfalse
                                              XML FormatIn the XML format, this property is represented as an attribute.
                                              Summaryfalse
                                              30. Extension.extension:drug.extension
                                              Definition

                                              An Extension

                                              ShortExtension
                                              Control0..0
                                              TypeExtension
                                              Is Modifierfalse
                                              Summaryfalse
                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                              ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                              SlicingThis element introduces a set of slices on Extension.extension.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                              • value @ url
                                              • 32. Extension.extension:drug.url
                                                Definition

                                                Source of the definition for the extension code - a logical name or a URL.

                                                Shortidentifies the meaning of the extension
                                                Comments

                                                The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.

                                                Control1..1
                                                Typeuri
                                                Is Modifierfalse
                                                XML FormatIn the XML format, this property is represented as an attribute.
                                                Summaryfalse
                                                Fixed Valuedrug
                                                34. Extension.extension:drug.value[x]
                                                Definition

                                                Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).

                                                ShortValue of extension
                                                Control0..1
                                                BindingThe codes SHALL be taken from Adverse Event Mitigation Drugs Value Set
                                                (required to http://onconova.github.io/fhir/ValueSet/onconova-vs-adverse-event-mitigation-drugs)
                                                TypeCodeableConcept
                                                [x] NoteSeeChoice of Data Typesfor further information about how to use [x]
                                                Is Modifierfalse
                                                Summaryfalse
                                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                36. Extension.extension:procedure
                                                Slice Nameprocedure
                                                Definition

                                                Procedure performed to mitigate the adverse event.

                                                ShortMitigation Procedure
                                                Control0..1
                                                TypeExtension
                                                Is Modifierfalse
                                                Obligations
                                                  ObligationsActor
                                                  SHALL:populate-if-knownCreator (Onconova)
                                                  SHOULD:persistConsumer (Onconova)
                                                  Summaryfalse
                                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                  ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                  38. Extension.extension:procedure.id
                                                  Definition

                                                  Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                  ShortUnique id for inter-element referencing
                                                  Control0..1
                                                  Typestring
                                                  Is Modifierfalse
                                                  XML FormatIn the XML format, this property is represented as an attribute.
                                                  Summaryfalse
                                                  40. Extension.extension:procedure.extension
                                                  Definition

                                                  An Extension

                                                  ShortExtension
                                                  Control0..0
                                                  TypeExtension
                                                  Is Modifierfalse
                                                  Summaryfalse
                                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                  ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                  SlicingThis element introduces a set of slices on Extension.extension.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                                  • value @ url
                                                  • 42. Extension.extension:procedure.url
                                                    Definition

                                                    Source of the definition for the extension code - a logical name or a URL.

                                                    Shortidentifies the meaning of the extension
                                                    Comments

                                                    The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.

                                                    Control1..1
                                                    Typeuri
                                                    Is Modifierfalse
                                                    XML FormatIn the XML format, this property is represented as an attribute.
                                                    Summaryfalse
                                                    Fixed Valueprocedure
                                                    44. Extension.extension:procedure.value[x]
                                                    Definition

                                                    Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).

                                                    ShortValue of extension
                                                    Control0..1
                                                    BindingThe codes SHALL be taken from Adverse Event Mitigation Procedures Value Set
                                                    (required to http://onconova.github.io/fhir/ValueSet/onconova-vs-adverse-event-mitigation-procedures)
                                                    TypeCodeableConcept
                                                    [x] NoteSeeChoice of Data Typesfor further information about how to use [x]
                                                    Is Modifierfalse
                                                    Summaryfalse
                                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                    46. Extension.extension:management
                                                    Slice Namemanagement
                                                    Definition

                                                    Management strategies employed to address the adverse event.

                                                    ShortManagement
                                                    Control0..1
                                                    TypeExtension
                                                    Is Modifierfalse
                                                    Obligations
                                                      ObligationsActor
                                                      SHOULD:populate-if-knownCreator (Onconova)
                                                      MAY:persistConsumer (Onconova)
                                                      Summaryfalse
                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                      ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                      48. Extension.extension:management.id
                                                      Definition

                                                      Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                      ShortUnique id for inter-element referencing
                                                      Control0..1
                                                      Typestring
                                                      Is Modifierfalse
                                                      XML FormatIn the XML format, this property is represented as an attribute.
                                                      Summaryfalse
                                                      50. Extension.extension:management.extension
                                                      Definition

                                                      An Extension

                                                      ShortExtension
                                                      Control0..0
                                                      TypeExtension
                                                      Is Modifierfalse
                                                      Summaryfalse
                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                      ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                      SlicingThis element introduces a set of slices on Extension.extension.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                                      • value @ url
                                                      • 52. Extension.extension:management.url
                                                        Definition

                                                        Source of the definition for the extension code - a logical name or a URL.

                                                        Shortidentifies the meaning of the extension
                                                        Comments

                                                        The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.

                                                        Control1..1
                                                        Typeuri
                                                        Is Modifierfalse
                                                        XML FormatIn the XML format, this property is represented as an attribute.
                                                        Summaryfalse
                                                        Fixed Valuemanagement
                                                        54. Extension.extension:management.value[x]
                                                        Definition

                                                        Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).

                                                        ShortValue of extension
                                                        Control0..1
                                                        BindingThe codes SHALL be taken from Adverse Event Mitigation Managements Value Set
                                                        (required to http://onconova.github.io/fhir/ValueSet/onconova-vs-adverse-event-mitigation-managements)
                                                        TypeCodeableConcept
                                                        [x] NoteSeeChoice of Data Typesfor further information about how to use [x]
                                                        Is Modifierfalse
                                                        Summaryfalse
                                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                        56. Extension.url
                                                        Definition

                                                        Source of the definition for the extension code - a logical name or a URL.

                                                        Shortidentifies the meaning of the extension
                                                        Comments

                                                        The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.

                                                        Control1..1
                                                        Typeuri
                                                        Is Modifierfalse
                                                        XML FormatIn the XML format, this property is represented as an attribute.
                                                        Summaryfalse
                                                        Fixed Valuehttp://onconova.github.io/fhir/StructureDefinition/onconova-ext-adverse-event-mitigation
                                                        58. Extension.value[x]
                                                        Definition

                                                        Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).

                                                        ShortValue of extension
                                                        Control0..0
                                                        TypeChoice of: base64Binary, boolean, canonical, code, date, dateTime, decimal, id, instant, integer, markdown, oid, positiveInt, string, time, unsignedInt, uri, url, uuid, Address, Age, Annotation, Attachment, CodeableConcept, Coding, ContactPoint, Count, Distance, Duration, HumanName, Identifier, Money, Period, Quantity, Range, Ratio, Reference, SampledData, Signature, Timing, ContactDetail, Contributor, DataRequirement, Expression, ParameterDefinition, RelatedArtifact, TriggerDefinition, UsageContext, Dosage, Meta
                                                        Is Modifierfalse
                                                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                        Summaryfalse
                                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))